Favorite Datasets from Early (and Late) Phases of Drug Research
Thomas E. Bradstreet, Ph.D.
Merck Research Labs
North Wales, PA 19454
thomas_bradstreet@merck.com
Part 1
- Table 1 - Oral Fertility Study in Male and Female Rats
- Table 2 - Bioequivalence Study
- Table 3 - Dose Response/Selection Study in GERD Patients
Part 2
- Table 1 - Exploratory Teratology Study in Rats
Description
and Data Table
Text File Dataset
Table 2 - Swim Maze Testing in Rat Pups
Table 3 - Oral Toxicity Study in Dogs
Table 4 - Exploratory Pharmacokinetic Study
Table 5 - Food Interaction Study
Table 6 - Pharmacokinetic Study of Carbidopa
Part 3
- Table 1 - Organ Weight Study in Rats
Description
and Data Table
Text File Dataset
Table 2 - Developmental Signs Testing in Rat Pups
Table 3 - Blood Pressure Study
Table 4 - Drug Interaction Study
Table 5 - Bioequivalence Study
Table 6 - Method Comparison Study
Table 7 - Combination Therapy Bioequivalence Study
Part 4
- Table 1 - Oral Teratogenic Study in Mice
Description
and Data Table
Text File Dataset
Table 2 - Hexobarbital-Metabolizing Enzyme Induction Study in Mice
Table 3 - Four Acute Toxicity Studies in Rodents
Table 4 - Sister Chromatid Exchange (SCE) Study in Mice
Table 5 - Alcohol Interaction Study in Men
Table 6 - Oral Contraceptive Interaction Study
Table 7 - Cost and Esophageal Healing
Part 5
- Table 1 - Developmental Signs Testing in Rat Pups
Description
and Data Table
Text File
Dataset
Table 2 - Bioequivalence Study
Table 3 - Dose Proportionality Study - AUC
Table 4 - Dose Proportionality Study
Table 5 - Multiple vs. Single Dose Comparison
Table 6 - Elderly vs. Young Comparison
Part 6
- Table 1 - Relative Bioavailability Study
Description
and Data Table
Text File
Dataset
Table 2 - Dose Proportionality in Elderly
Table 3 - Ocular Irritation Study-Rabbits
Table 4 - Single Rising Dose Pharmacokinetic Study
Table 5 - Multiple vs. Single Dose Comparison
Sources
Bradstreet, T. E. (1991) "Some Favorite Data Sets from Early Phases of Drug
Research." Proceedings of the Section on Statistical Education of the American
Statistical Association.
Bradstreet, T. E. (1992) "Favorite Data Sets from Early Phases of Drug Research -
Part 2." Proceedings of the Section on Statistical Education of the American
Statistical Association.
Bradstreet, T. E. (1994) "Favorite Data Sets from Early Phases of Drug Research -
Part 3." Proceedings of the Section on Statistical Education of the American
Statistical Association.
Bradstreet, T. E. and Liss, C. L. (1995) "Favorite Data Sets from Early (and Late)
Phases of Drug Research - Part 4." Proceedings of the Section on Statistical
Education of the American Statistical Association.
Bradstreet, T. E. and Short, T. H. (2001) "Favorite Data Sets from Early (and
Late) Phases of Drug Research - Part 5." Proceedings of the Section on Statistical
Education of the American Statistical Association.
Bradstreet, T. E. and Short, T. H. (2006) "Favorite Data Sets from Early
Phases of Drug Research - Part 6." Proceedings of the Section on Statistical
Education of the American Statistical Association.