Dose AUC Cmax Tmax Sub I II III I II III I II III I II III 1 100 25 50 604.0 240.4 364.6 137.0 61.1 95.3 1.5 2.0 1.0 2 25 50 100 139.7 352.9 1086.6 44.4 101.0 225.0 1.0 1.0 2.0 3 50 100 25 386.0 766.1 190.8 86.6 204.0 44.6 1.5 1.0 1.5 4 50 100 25 174.7 878.2 148.0 46.4 245.0 53.8 1.5 2.0 1.0 5 50 25 100 604.9 140.6 668.3 194.0 29.7 143.0 0.5 2.0 1.0 6 25 100 50 168.7 835.8 355.6 44.9 223.0 90.6 1.0 1.0 1.5 7 100 50 25 1004.6 264.0 123.9 318.0 81.2 55.0 1.0 0.5 1.0 8 25 100 50 114.1 475.1 369.9 29.0 137.0 86.3 1.0 1.0 1.0 9 50 25 100 541.5 336.4 1533.0 119.0 86.8 399.0 2.0 1.0 1.5 10 25 50 100 222.0 404.3 917.3 58.4 105.0 231.0 2.0 3.0 3.0 11 100 50 25 885.3 299.4 76.5 208.0 74.2 25.0 2.0 1.5 0.5 12 100 25 50 1042.9 116.0 169.6 259.0 29.6 49.8 1.5 2.0 1.0