Favorite Datasets from Early Phases of Drug Research

Oral Toxicity Study in Dogs

Part 2 - Table 3

Sixteen male and 16 female dogs were assigned randomly to treatment with either a Vehicle Control or to one of three graded doses (8, 25, 75 mg/kg) of an investigational compound. Four dogs of each sex were assigned to each treatment group. Oral dosing by gavage was performed once daily, seven days a week, for a period of 12 consecutive weeks. Prior to treatment and again at Weeks 4, 8, and 12, blood samples were collected from the jugular vein of each animal following overnight starvation. Alkaline phosphatase levels (U/L) were assayed from the blood samples.

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Part 2 - Table 3
Oral Toxicity in Dogs
Alkaline Phosphatase Levels (U/L)
Males Females
DoseWeek DoseWeek
(mg/kg)Dog04812 (mg/kg)Dog04812
0 101 169 136 125 122          0 151 125 105 92 86
102 291 282 218 154 152 138 94 81 72
103 158 128 104 91 153 113 91 81 72
104 122 113 91 82 154 137 94 79 75
8 201 203 171 141 109 8 251 170 150 125 121
202 178 154 127 114 252 139 127 103 94
203 141 104 90 80 253 131 152 112 99
204 181 143 120 125 254 125 105 91 82
25 301 101 80 78 83 25 351 113 101 89 122
302 199 149 147 142 352 150 113 105 90
303 141 138 118 108 353 155 161 134 116
304 149 131 133 134 354 133 197 218 159
75 401 135 218 204 226 75 452 113 148 122 143
402 153 164 148 146 453 102 191 172 162
403 147 192 205 167 454 128 226 261 279
404 157 168 168 165 455 91 173 156 202

Source:

Bradstreet, T.E. (1992) "Favorite Data Sets from Early Phases of Drug Research - Part 2." Proceedings of the Section on Statistical Education of the American Statistical Association.

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Last modified November 25, 2003 - THS