Drug A                  Metabolite                   Drug B
 S         AUC            Cmax        AUC           Cmax         AUC           Cmax 
 u      (ng*hr/ml)      (ng/ml)    (ng*hr/ml)      (ng/ml)    (ng*hr/ml)     (ng/ml) 
 b Seq   C      S      C     S     C       S       C     S     C      S      C     S  
 1 SC 493.62 582.11 243.1 333.0 3108.40 2888.52 494.8 459.3 298.52 368.37  39.4  65.2
 4 SC 645.78 552.67 285.8 143.5 1667.97 1558.98 168.8 133.4 411.09 456.08  82.8  54.5
 6 SC 508.33 465.43 378.7 290.3 1668.81 1915.03 265.9 337.6 363.81 331.09  53.1  53.0
 7 SC 563.36 597.42 115.1 347.5 2151.54 2060.68 198.3 192.1 397.08 405.17  54.7  81.8
 9 SC 357.33 405.31 142.3 201.3 1146.28 1236.48  84.8 103.8 452.10 669.55  68.8 107.3
11 SC 233.28 258.80 102.1 151.4 1377.62 1649.46 140.0 189.2 417.32 661.40  43.2  62.6
13 SC 326.40 338.01 139.3 278.6 2764.74 2707.75 355.5 357.4 500.91 593.49  67.3  79.0
15 SC 313.52 276.35 165.0 167.7 2033.78 2102.87 183.3 212.1 431.55 417.19  73.0  81.5
 2 CS 382.21 370.89 246.2 180.8 2348.63 2181.62 303.9 245.7 526.03 509.83  99.3  76.3
 3 CS 435.09 447.63 212.4 173.3 2773.75 2783.86 360.7 354.3 379.20 603.85  80.6  85.6
 5 CS 689.09 514.11 357.3 172.4 3575.11 2922.28 503.7 315.0 526.00 469.37 131.2 100.2
 8 CS 372.61 343.09 174.5 356.2 2588.72 2456.53 313.3 348.5 439.16 350.74  80.7  56.2
10 CS 450.85 407.61 298.3 211.8 2256.81 2220.35 335.1 306.3 508.40 591.89  90.3  78.1
12 CS 503.59 486.86 333.9 137.2 2520.15 2237.74 356.0 277.5 417.03 426.69  93.2  65.9
14 CS 686.34 643.01 308.7 398.1 2958.28 3072.02 306.2 296.8 455.71 501.08  55.8  73.4
16 CS 332.50 331.50 303.7 135.7 2280.09 2078.79 272.8 241.9 512.46 568.80  55.9  63.1