No Treatment Treatment 1 Treatment 2 Treatment 3 Treatment 4 S R TS P Cmax AUC Tmax P Cmax AUC Tmax P Cmax AUC Tmax P Cmax AUC Tmax P Cmax AUC Tmax 1 N 1 4 26.02 33.90 0.33 1 22.96 28.17 0.50 2 33.56 40.94 0.50 5 19.54 30.46 0.75 3 19.91 27.04 0.50 2 N 5 1 17.37 19.60 0.33 2 15.64 15.47 0.33 5 12.92 15.85 0.75 3 19.22 24.34 0.50 4 12.00 11.31 0.33 3 N 4 2 10.95 15.62 0.75 5 13.36 17.66 0.75 3 10.74 13.77 0.50 4 13.86 18.02 0.50 1 16.08 20.24 0.75 4 N 9 3 34.99 43.12 0.50 2 22.59 33.12 0.33 5 19.82 32.11 1.00 4 23.00 35.17 0.50 1 22.32 32.34 0.33 5 N 7 5 11.81 21.95 1.00 4 15.04 26.76 0.75 1 12.61 17.98 0.50 3 15.24 25.17 0.75 2 16.11 30.60 0.75 6 N 2 3 25.95 37.12 0.33 4 26.42 32.77 0.75 1 17.70 15.72 0.50 2 24.89 34.92 0.50 5 27.34 35.35 0.50 7 N 8 2 25.77 34.79 0.50 5 18.89 31.52 1.00 4 34.02 30.06 0.33 1 17.29 18.37 0.75 3 21.26 34.26 0.50 8 N 10 1 4.99 8.10 1.00 3 10.87 16.22 1.00 2 9.75 10.45 0.50 5 10.35 17.18 1.50 4 11.79 19.67 1.00 9 N 3 5 10.80 15.18 0.50 3 10.98 11.10 0.50 4 14.79 15.45 0.50 1 7.65 8.14 0.50 2 7.96 7.84 0.17 10 N 6 4 8.79 12.59 0.50 1 12.82 15.42 0.33 3 15.30 28.78 1.00 2 12.95 22.16 0.75 5 13.62 24.99 1.00 11 N 4 2 12.61 15.92 0.75 5 13.08 19.93 1.00 3 7.04 7.21 0.75 4 20.75 28.92 0.50 1 14.71 15.87 0.50 12 N 3 5 8.37 8.08 0.33 3 8.15 7.71 0.50 4 17.16 23.57 0.50 1 7.07 8.27 0.33 2 7.83 9.66 0.75 13 N 10 1 6.39 9.78 0.75 3 14.68 21.53 0.50 2 15.38 22.56 1.00 5 14.37 22.33 0.75 4 13.46 24.13 0.50 14 N 2 3 21.64 37.46 0.75 4 17.35 24.28 0.33 1 18.32 27.68 0.50 2 30.68 54.70 0.75 5 19.94 41.05 1.00 15 A 6 4 19.17 27.98 0.50 1 13.05 17.04 0.75 3 16.48 22.05 0.75 2 14.32 21.70 0.75 5 13.26 18.13 0.75 16 A 9 3 7.45 7.43 1.00 2 8.40 8.48 0.50 5 6.36 7.19 1.00 4 10.68 9.11 0.50 1 10.55 14.76 1.00 17 N 1 4 7.28 9.71 1.00 1 7.78 8.93 0.50 2 15.01 23.57 0.75 5 14.49 21.04 0.50 3 13.42 18.19 1.00 18 A 5 1 13.34 12.92 0.50 2 11.57 16.37 0.75 5 11.97 13.83 0.75 3 6.49 7.85 0.17 4 14.24 16.33 0.50 19 N 7 5 12.27 19.30 1.00 4 8.45 13.27 1.00 1 8.85 11.94 1.00 3 12.98 16.90 0.75 2 9.52 16.18 1.00 20 N 8 2 13.51 14.47 0.33 5 22.31 29.95 0.50 4 22.27 29.10 0.50 1 13.29 19.31 0.50 3 17.89 17.31 0.50 21 A 1 4 8.27 7.07 0.50 1 7.34 11.24 1.00 2 0 0 . 5 5.59 7.04 0.75 3 2.40 1.44 1.00 22 A 5 1 10.41 18.00 0.50 2 9.18 9.71 0.33 5 5.48 5.84 0.75 3 8.75 13.11 0.50 4 10.72 14.30 0.33 23 A 7 5 2.87 1.17 0.75 4 2.20 0.55 0.75 1 6.68 4.96 0.50 3 5.63 2.63 0.50 2 4.45 2.20 0.33