Ethinyl Estradiol Norethindrone AUC CMax AUC CMax Sub Seq Drug Pbo Drug Pbo Drug Pbo Drug Pbo 1 P/D 3744.8 2623.0 366 279 197117.5 197525.0 21600 21900 2 D/P 3756.2 2511.0 300 172 176487.5 198357.5 25100 23300 3 P/D 2480.0 2227.7 253 252 184745.0 151957.5 22900 23200 4 D/P 2986.9 3177.2 284 295 116305.0 133092.5 16400 18100 5 D/P 3858.2 3176.9 467 373 125869.0 156413.8 21600 22400 6 P/D 4642.2 4493.7 435 513 164875.0 156367.5 13400 17200 7 P/D 2879.7 2985.3 298 313 195862.5 184942.5 20800 24300 8 D/P 3328.1 2941.4 431 302 118340.0 148220.0 18100 24200 9 D/P 3005.8 3033.9 306 288 176590.0 205315.0 17800 54200 10 P/D 2498.4 1919.7 325 243 138015.0 123012.5 22400 20500 11 P/D 2266.6 2496.1 190 227 155122.5 122987.5 10100 14300 12 D/P 5624.5 5044.3 651 591 207327.5 190987.5 26600 28200 13 P/D 3514.8 3016.0 324 317 176055.0 173565.0 25500 24900 14 D/P 3354.9 2343.5 326 292 197912.5 206160.0 40100 31300 15 P/D 3214.7 2985.2 277 303 186815.0 156367.5 21300 21300 16 D/P 3282.8 2383.1 314 335 182250.0 199877.5 21800 26700 17 P/D 3580.9 3385.5 349 369 204687.5 201557.5 25600 34400 18 D/P 5018.0 4161.7 462 500 278532.5 271885.0 24200 36600 19 P/D 2982.8 2622.0 283 266 189285.0 155790.0 16300 19400 20 D/P 2472.0 1936.7 370 204 86467.5 93730.0 12700 13200 21 D/P 3819.6 2760.7 335 389 142359.8 150215.0 24600 28000 22 P/D 4333.3 3863.5 362 288 253460.0 232197.5 27200 28600