Dose Proportionality Study - AUC 500 mg 1000 mg 2000 mg 3000 mg Sub Sex Seq Per Tot Un Per Tot Un Per Tot Un Per Tot Un 1 M 4 4 566.6 28.2 3 604.6 29.9 1 434.1 30.7 2 393.5 33.0 2 M 3 3 607.2 25.0 1 549.7 29.1 2 450.9 26.3 4 374.0 28.1 3 M 2 2 504.2 23.0 4 475.5 23.9 3 396.2 23.6 1 405.2 28.4 4 M 1 1 616.6 29.8 2 514.3 28.0 4 615.7 40.3 3 514.8 40.6 5 M 3 3 736.2 37.2 1 697.3 46.8 2 552.9 42.4 4 683.4 54.0 6 M 1 1 527.2 31.8 2 498.0 32.2 4 456.3 36.3 3 422.9 35.0 7 M 2 2 685.6 38.8 4 689.3 34.5 3 532.2 42.2 1 460.0 49.9 8 M 4 4 538.4 27.0 3 572.8 28.2 1 507.0 34.5 2 415.7 36.3 9 F 2 2 589.8 32.8 4 657.9 40.0 3 533.2 40.7 1 519.0 45.8 10 F 3 3 758.4 38.6 1 587.1 35.3 2 503.4 44.6 4 490.5 41.9 11 F 1 1 664.0 30.4 2 587.9 32.1 4 565.0 38.5 3 523.0 37.1 12 F 4 4 571.8 31.4 3 508.5 32.2 1 552.6 44.6 2 406.4 40.3 13 F 4 4 632.4 32.2 3 629.9 33.4 1 515.4 41.2 2 473.7 48.2 14 F 2 2 536.0 34.4 4 530.1 38.8 3 496.3 46.2 1 457.4 51.9 15 F 1 1 647.6 34.0 2 534.8 31.6 4 551.3 42.9 3 537.6 51.1 16 F 3 3 596.8 30.6 1 516.6 35.8 2 428.8 38.5 4 428.3 43.5