2.5 mg 5 mg 10 mg 15 mg Sub Sex Seq Per AUC Cmax Per AUC Cmax Per AUC Cmax Per AUC Cmax 1 M 2 3 24.6 9.11 1 32.4 7.99 2 86.1 18.01 4 158.0 42.04 2 M 3 4 26.7 6.96 3 32.0 9.35 1 77.4 25.15 2 158.0 47.63 3 M 1 1 20.8 5.11 2 42.3 14.41 4 72.1 22.80 3 113.0 33.29 4 M 1 1 8.29 2.88 2 22.1 10.38 4 51.6 14.43 3 73.2 21.64 5 M 4 2 11.0 6.26 4 32.9 16.31 3 62.2 29.96 1 125.3 47.98 6 M 4 2 4.94 3.61 4 17.7 7.02 3 40.6 19.65 1 62.0 25.84 7 M 2 3 21.8 12.48 1 46.0 17.90 2 92.5 29.12 4 178.0 55.57 8 M 2 3 8.45 3.65 1 21.9 8.14 2 34.4 15.05 4 63.7 30.40 9 M 1 1 18.0 7.48 2 35.8 11.06 4 80.6 37.63 3 118.0 50.20 10 M 4 2 15.5 8.36 4 43.1 23.66 3 92.8 60.13 1 163.0 88.61 11 M 3 4 19.5 3.96 3 37.7 13.43 1 108.0 45.94 2 199.0 56.17 12 M 3 4 12.3 4.98 3 30.2 12.60 1 66.0 24.93 2 117.0 38.64 13 F 1 1 25.4 5.83 2 65.5 19.05 4 154.0 51.98 3 262.0 88.87 14 F 3 4 9.1 3.48 3 24.7 8.96 1 51.3 18.04 2 102.0 29.16 15 F 2 3 13.1 3.69 1 28.4 10.92 2 59.2 17.45 4 107.0 38.87 16 F 2 3 17.5 6.71 1 43.5 15.19 2 104.0 41.51 4 139.0 39.27 17 F 3 4 27.8 5.85 3 57.2 16.42 1 97.8 24.60 2 159.0 40.80 18 F 1 1 19.7 4.98 2 45.1 10.71 4 95.8 24.38 3 196.0 59.47 19 F 1 1 15.6 4.79 2 38.1 9.68 4 104.0 22.97 3 154.0 38.21 20 F 4 2 16.8 4.91 4 32.5 8.36 3 74.7 27.81 1 139.0 44.82 21 F 3 4 17.4 7.93 3 40.0 14.17 1 92.8 29.35 2 156.0 64.67 22 F 4 2 22.8 6.46 4 36.4 10.36 3 91.0 45.35 1 163.0 57.78 23 F 4 2 20.4 8.37 4 49.6 17.52 3 131.0 48.29 1 187.0 63.22 24 F 2 3 18.9 9.76 1 39.9 16.44 2 105.0 33.32 4 169.0 87.72