AUC Cmax Panel Sub Cpd 10mg 20mg 40mg 10mg 20mg 40mg 1 1 P 91.5 217.8 330.7 42.4 82.0 241.3 M 395.6 728.3 2170.2 39.6 70.0 310.5 2 P 96.6 82.1 705.0 29.2 68.9 202.8 M 714.1 630.7 1728.5 25.4 47.1 197.0 3 P NA 146.4 266.9 30.2 124.3 117.0 M 334.2 856.4 1650.7 45.3 113.7 248.1 4 P NA 84.4 140.4 NA 105.8 103.2 M 370.8 707.7 982.3 30.0 70.9 117.8 5 P NA NA NA NA NA NA M NA NA NA NA NA NA 6 P NA 116.7 229.8 NA 25.2 74.4 M NA NA NA NA NA NA 7 P NA 215.1 426.2 25.5 52.1 139.9 M 571.1 978.0 1863.6 45.2 85.1 247.9 8 P NA 102.2 312.8 20.2 43.0 127.6 M 220.0 766.4 1664.0 26.6 78.0 266.2 40mg 80mg 120mg 40mg 80mg 120mg 2 9 P 378.2 901.7 1329.9 171.7 809.3 682.4 M 2211.9 5144.7 8151.4 204.4 702.8 1222.8 10 P 362.8 923.7 NA 239.5 498.4 NA M 1354.8 2865.2 NA 128.8 327.3 NA 11 P 353.9 778.4 996.0 197.0 372.2 710.3 M 1897.7 3336.0 4594.0 210.5 516.9 945.8 12 P 255.1 649.6 1123.4 326.0 477.0 947.0 M 1797.0 4183.2 6340.9 178.3 586.5 1032.8 13 P 526.1 927.6 1566.1 379.9 454.1 1288.7 M 940.5 1883.3 2857.9 110.0 228.1 493.7 14 P 1036.7 2115.5 2948.1 541.2 922.3 1758.7 M 2828.3 6153.9 8323.7 269.7 715.3 1094.2 15 P 359.5 845.3 1203.0 234.5 539.5 759.7 M 1855.1 3318.4 4512.2 199.2 445.8 875.2 16 P 188.2 319.9 537.6 125.4 226.8 392.8 M 1146.8 2229.3 3307.6 112.4 322.0 652.1 120mg 150mg 200mg 120mg 150mg 200mg 3 17 P 1323.2 2076.8 2917.6 828.4 1195.8 2213.6 M 5486.3 9339.0 10953.6 695.2 1263.2 1730.0 18 P 1648.4 1726.3 2344.0 1098.3 1139.9 2049.8 M 6349.5 7908.5 9703.9 1074.1 1376.3 1890.9 19 P 1709.6 1829.0 3245.5 1299.2 1117.5 2447.4 M 5515.3 5776.8 7694.9 921.6 895.9 1224.1 20 P 649.8 1343.8 2040.0 401.6 1053.8 2124.9 M 4645.0 6782.7 7080.4 934.2 1338.2 1863.0 21 P 871.0 1674.7 2370.3 562.8 1681.7 2526.9 M 3450.0 4684.1 5842.8 771.3 1113.4 1309.9 22 P 1289.0 1562.6 2462.8 900.7 661.6 1925.6 M 6803.3 8677.2 11885.2 967.9 1412.8 2406.2 23 P 948.2 1220.9 2091.1 548.0 694.4 2760.9 M 3926.1 4727.5 6029.7 740.1 953.3 1674.9 24 P 1022.1 1990.2 2730.7 819.2 1583.7 1217.0 M 5742.9 6559.2 8146.4 1194.8 1579.6 1601.4 200mg 250mg 300mg 200mg 250mg 300mg 4 25 P 2358.6 2688.1 3459.6 1627.8 1711.7 2407.8 M 11114.6 12873.2 15159.7 2856.0 3062.9 2941.7 26 P 1913.3 1990.2 1961.0 2034.6 945.4 892.2 M 6910.2 6270.3 6688.4 1233.4 1242.4 1281.2 27 P 3753.1 3934.5 4449.5 4398.4 4625.8 4648.2 M 9932.1 12219.3 11192.6 1693.8 2213.8 2413.2 28 P 3066.3 3966.3 6527.5 2717.2 3366.3 5420.5 M 7512.8 9354.6 13069.9 1984.9 2400.4 3012.7 29 P 1803.3 2469.5 3268.2 2364.6 2360.4 3240.6 M 7657.6 10173.0 12212.7 1622.3 2304.4 2895.6 30 P NA NA NA NA NA NA M NA NA NA NA NA NA 31 P 1412.2 1724.5 2769.7 1468.5 1161.0 1902.6 M 5219.3 5391.6 7108.8 1232.2 1442.3 1920.9 32 P 1065.2 1198.2 2011.2 782.7 660.5 1580.4 M 6094.8 7122.5 8394.4 1454.6 1613.1 1824.7